Role: Your work will contribute to establishing a precision senolytic approach that selectively eliminates pathological senescent cells in the fibrotic lung while sparing healthy tissue. In this role, you will: Establish and characterize models of cellular senescence relevant to fibrotic lung disease, spanning primary human cells, iPSC-derived cells, and in vivo fibrosis models. Identify and validate cell-surface markers that distinguish pathological senescent cells from healthy tissue, prioritizing candidates with a favorable safety profile. Develop and engineer immune effector–based strategies to selectively eliminate senescent cells in the fibrotic lung. Evaluate senolytic efficacy and its impact on fibrosis across disease-relevant human tissue and in vivo models. Collaborate with cross-functional teams and external academic partners, present findings at major scientific conferences, and publish as first author. Basic Qualifications: PhD in Immunology, Cell Biology, Molecular Biology, Aging Biology, or a closely related field. Demonstrated experience with cellular senescence and at least one of: fibrosis, aging biology, immunology, therapeutic modality engineering (e.g., cell therapy, antibody, or protein engineering), or analytical approaches such as proteomics or single-cell analysis. Strong publication record demonstrating scientific productivity and independence. Additional Skills/Preferences: Self-directed, motivated, and pursuing research/publication goals. Excellent oral/written communication and presentation skills; strong publication record. Interest/background in cellular senescence, fibrosis biology, translational drug discovery, and relevant cellular/in vivo models. Hands-on immunology/immune cell biology; experience with therapeutic modality development; proteomic/transcriptomic/high-parameter single-cell and imaging approaches; human iPSC culture/directed differentiation; disease-relevant human tissue and/or in vivo fibrosis models; strong multi-modal analytical skills. Application/Eligibility: Must be authorized to work in the United States full-time; Lilly will not provide sponsorship for visas/work authorization. Not permanent; requires US citizenship or permanent resident status; fixed duration of two years (potential to extend to three years, up to four). #J-18808-Ljbffr Scorpion Therapeutics
...Doctor of Medicine | Internal Medicine - General/Other Location: Minnesota Employer: ARR Healthcare Pay: Competitive weekly pay... ...Minnesota Lake Country. We are seeking an internal medicine physician to join a growing team. The practice offers a wide...
About TOP Jewish Foundation TOP Jewish Foundation ("TOP") is the community foundation serving Jewish Federations, community organizations, and philanthropists throughout West Coast and Central Florida. Founded in 1980, TOP is a 501(c)(3) nonprofit organization dedicated...
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